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Physical & Chemical properties

Boiling point

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boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010-05-19 to 2010-05-25
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: A GLP study conducted to current accepted guidelines.
according to guideline
OECD Guideline 103 (Boiling point/boiling range)
according to guideline
EU Method A.2 (Boiling Temperature)
Principles of method if other than guideline:
The boiling point was determined using a digital melting point device (Büchi B540 Melting Point Unit, No.: 908281) with a temperature range up to 400 °C (673 K). A small amount of Great Lakes DBS was placed in a capillary glass tube with a diameter of 3.2 mm to obtain a filling level of approximately 5 mm. The tube was heated in the oven of the device. A preliminary study was initially performed with two parallel samples at a 10 °C/min heating rate until boiling was observed.

The main test was performed with two capillaries containing the test item were placed into the apparatus and the block was heated from 330 °C to 400 °C at a 0.5 °C/min heating rate. The sample was observed visually through a magnifying glass. The end temperature was registered when a quick continuous flow of bubbles was formed at the sealed end of the capillary resting in the heating block. The experiment was repeated three times with two parallel measurements each. The mean of the six measurements was reported. The atmospheric pressure was registered.
GLP compliance:
yes (incl. QA statement)
Principles of Good Laboratory Practice (Hungarian GLP Regulations: 9/2001 (III. 30) EüM-FVM joint decree of the Minister of Health and the Minister of Agriculture and Regional Development which corresponds to the OECD GLP, ENV/MC/CHEM (98) 17.)
Type of method:
other: capillary method, measurements taken by visual observations with a magnifying glass
Boiling pt.:
369.7 °C
Atm. press.:
97.5 - 98.2 kPa
Remarks on result:
other: ± 0.05 °C (95% CI)

Table 1: Measured temperatures corresponding to the boiling point of Great Lakes DBS (three experiments (I, II, III)) with two parallel samples each (1, 2)


Measured Temperatures during the Main Study (°C)








Boiling point








On the day of the experiment the instrument was checked by determining the boiling point of the reference substance α-naphthylamine (Batch No.: S4699491). The boiling point is 301± 1°C (Vegyészek Zsebkönyve, Műszaki Kiadó 1963)

The boiling point of Great Lakes DBS was found to be 369.7 ± 0.05 °C (95 % confidence interval), (642.9 K) at an atmospheric pressure of 97.5-98.2 kPa.
Executive summary:

In a GLP study conducted to current accepted guidelines (OECD 103 and EU method A.2), the boiling point of Great Lakes DBS was deterimed to be 369.7 ± 0.05 °C (95 % confidence interval), (642.9 K) at an atmospheric pressure of 97.5-98.2.

Description of key information

The boiling point of Generic DBS was determined to be 369.7 ± 0.05 °C (95 % confidence interval), (642.9 K) at 97.5 and 98.2 kPa at atmospheric pressure.

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
369.7 °C

Additional information

The key study Sávári Z & Kiss G (2010) was performed to current accepted guidelines (OECD 103 and EU method A.2) and in compliance with GLP. The study was considered to be adequate as a standalone study to fulfil this data requirement. The study was assigned a reliability score of 1.