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EC number: 215-947-7 | CAS number: 1458-18-0
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 February 2013 - 03 May 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- (2009)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- (2006)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7950 (Vapor Pressure)
- Version / remarks:
- (1996)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate
- EC Number:
- 215-947-7
- EC Name:
- Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate
- Cas Number:
- 1458-18-0
- Molecular formula:
- C6H5Cl2N3O2
- IUPAC Name:
- methyl 3-amino-5,6-dichloropyrazine-2-carboxylate
- Test material form:
- solid: particulate/powder
- Details on test material:
- Identification: Amiloride Compound 7
Molecular formula: C6H5Cl2N3O2
Molecular weight: 222.03
CAS Number:1458-18-0
Description: Tan powder
Batch: 206-2
Purity/Composition: 99.7 area%
Test substance storage: In refrigerator (2-8°C) protected from light, desiccated
Stability under storage conditions: Stable
Expiry date: 11 May 2014 (Retest date)
Constituent 1
Results and discussion
Vapour pressureopen allclose all
- Temp.:
- 25 °C
- Vapour pressure:
- 7.2 other: E-05 Pa
- Temp.:
- 20 °C
- Vapour pressure:
- 3.2 other: E-05 Pa
Any other information on results incl. tables
Results of the isothermal TGA analysis
Temperature [°C] |
Weight loss [µg/min] |
νT [g/cm2/h] |
logνT |
logPT |
120 |
5.042 |
6.02 E-4 |
-3.22 |
0.93 |
3.849 |
4.59 E-4 |
-3.34 |
0.80 |
|
130 |
11.21 |
1.34 E-3 |
-2.87 |
1.29 |
10.94 |
1.31 E-3 |
-2.88 |
1.28 |
|
140 |
24.09 |
2.88 E-3 |
-2.54 |
1.64 |
24.50 |
2.92 E-3 |
-2.53 |
1.65 |
|
150 |
50.65 |
6.05 E-3 |
-2.22 |
1.98 |
51.87 |
6.19 E-3 |
-2.21 |
1.99 |
Vapour pressure regression curve: log PT = -6199x 1/T + 16.65 (r = 0.996, n= 8).
Log PT 20°C was calculated to be -4.50
Log PT 25°C was calculated to be -4.14
Applicant's summary and conclusion
- Conclusions:
- The vapour pressure of Amiloride Compound 7 was determined to be 7.2E-05 Pa at 25°C (3.2E-05 Pa at 20°C) using the isothermal thermogravimetric effusion method (GLP-compliant study in accordance with EC A.4, OECD 104 and EPA OPPTS 830.7950).
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