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EC number: 215-947-7 | CAS number: 1458-18-0
Surface tension
Administrative data
- Endpoint:
- surface tension
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 February 2013 - 03 May 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.5 (Surface Tension)
- Version / remarks:
- (2008)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 115 (Surface Tension of Aqueous Solutions)
- Version / remarks:
- (1995)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- OECD harmonised ring method
Test material
- Reference substance name:
- Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate
- EC Number:
- 215-947-7
- EC Name:
- Methyl 3-amino-5,6-dichloropyrazine-2-carboxylate
- Cas Number:
- 1458-18-0
- Molecular formula:
- C6H5Cl2N3O2
- IUPAC Name:
- methyl 3-amino-5,6-dichloropyrazine-2-carboxylate
- Test material form:
- solid: particulate/powder
- Details on test material:
- Identification: Amiloride Compound 7
Molecular formula: C6H5Cl2N3O2
Molecular weight: 222.03
CAS Number:1458-18-0
Description: Tan powder
Batch: 206-2
Purity/Composition: 99.7 area%
Test substance storage: In refrigerator (2-8°C) protected from light, desiccated
Stability under storage conditions: Stable
Expiry date: 11 May 2014 (Retest date)
Constituent 1
Results and discussion
Surface tension
- Surface tension:
- 74 mN/m
- Temp.:
- 20 °C
- Conc.:
- 90 vol%
Any other information on results incl. tables
Surface tension measurements
Measurement
|
Time passed [minutes]
|
Surface tension |
||
Individual
|
Mean
|
Mean corrected (1) |
||
|
|
|
|
|
1 |
18 |
74.3 |
|
|
2 |
19 |
74.1 |
74.0 |
74.7 |
3 |
20 |
73.9 |
|
|
4 |
21 |
73.9 |
|
|
5 |
22 |
74.0 |
|
|
(1) multiplied
by Φb followed by correction according to Harkins-Jordan.
Applicant's summary and conclusion
- Conclusions:
- The surface tension of an aqueous solution of the substance at 90% of the saturation concentration was determined to be 74.7 mN/m at 20°C using the OECD Harmonized ring method (GLP-compliant study in accordance with EC A.5 and OECD 115). Because this is not < 60 mN/m, Amiloride Compound 7 is not surface active according to the EC A.5 guideline.
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