Isooctyl mercaptoacetate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Exposure of rats to saturated vapours of IOTG generated at room temperature and at 135°C

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isooctyl mercaptoacetate

EC Number:

246-613-9

EC Name:

Isooctyl mercaptoacetate

Cas Number:

25103-09-7

Molecular formula:

C10H20O2S

IUPAC Name:

2-methylheptyl 2-sulfanylacetate

Details on test material:

Source: Evans Chemetics Inc., USA
Batch: ba-W-828-20
Purity: 99.5%

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

Groups of six male rats were exposed to vapours generated from test material at room temperature and at 135°C. An additional group of rats was maintained as controls for each material. The rats were exposed for 7 hours in a 19-litre exposure chamber. Air was bubbled through the material to be tested and the vapours generated passed to the chamber. Control animals were exposed to filtered room air.

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

7 h

Concentrations:

The nominal concentration to which animals were exposed was 43 ppm at room temperature and 1710 ppm at 135°C.  

No. of animals per sex per dose:

6

Control animals:

yes

Details on study design:

The animals were observed for signs of toxicity during the exposure and during a two-week post-exposure observation period. Body weights were recorded before the exposure, the day following and periodically during the post-exposure period. One animal from each group was sacrificed for gross pathological examination the day following the exposure and the remaining animals were sacrificed for gross examination at the end of the two-week post-exposure observation period.

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LC0

Effect level:

> 0.36 mg/L air (nominal)

Exp. duration:

7 h

Remarks on result:

other: vapours generated at room temperature

Effect levels 2

Sex:

male

Dose descriptor:

LC0

Effect level:

> 14.3 mg/L air (nominal)

Exp. duration:

7 h

Remarks on result:

other: vapours generated at 135°C

Mortality:

All animals survived the exposure to 43 ppm or 1710 ppm as well as the two week recovery period.  

Clinical signs:

other: No effect

Body weight:

No effect

Gross pathology:

Gross pathological examination revealed no treatment-related changes.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 of 16 December 2008

Conclusions:

No mortality at 0.36 mg/l at room temperature and 14.3 mg/l at 135°C

Executive summary:

Groups of 6 male rats were exposed to vapors of IOTG generated at room temperature (43 ppm) or at 135°C (1710 ppm) for 7 hours. Animals were observed for 14 days. There were no deaths and gross pathological examination revealed no treatment-related changes.