Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-877-4
CAS number: 89-04-3
A carcinogenicity study may be required in accordance with REACH Regulation 1907/2006, Annex X, Section 8.9.1 of Column 1, Annex X. It is proposed to waive the need to conduct this study on the basis that available information indicate no concerns for carcinogenicity.
A carcinogenicity study may be required in accordance with REACH
Regulation 1907/2006, Annex X, Section 8.9.1 of Column 1, Annex X. It is
proposed to waive the need to conduct this study on the basis of:
1) Negative findings in tests for
gene mutation / mutagenicity.
2) Molecular modelling studies
performed by Kambia et al. (Kambia N, Renault N, Dilly S, Farce A, Dine
T, Gressier B Luyckk M, Brunet C and Chavatte P. Molecular modelling of
phthalates – PPARs interactions. Journal of Enzyme Inhibition and
Medicinal Chemistry, 23(5): 611–616, 2008) indicate that TOTM, a
structural analogue of the registered substance derived from a C8
-branched alcohol rather than a C8 -linear alcohol, is not able to fit
into PPARα and PPARγ binding sites due to its larger size relative to
the corresponding phthalate ester, implying that any predicted activity
may not actually be able to occur.
With these considerations it is concluded that there is sufficient
evidence to justify the non-classification of the registered substance
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again