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EC number: 201-877-4
CAS number: 89-04-3
The tested substance was biodegraded by
65% at Day 28 in the Closed Bottle test. The time-day window concept
assumes that biodegradation of a single organic compound in a ready
biodegradability test is a growth-linked process which follows an
S-shaped growth curve. The tested substance may be regarded as
consisting of two chemicals linked together by ester bonds. Upon
hydrolysis the diester, then the monoester, and finally two compounds
are formed i.e. octanol and 1,2,4-benzenetricarboxylic acid which may
then be further degraded. The biodegradation kinetics (lag period,
growth rate, and yield) of the individual hydrolysis products are not
necessarily the same. The time window applied as a validity criterion to
Closed Bottle tests is therefore considered not applicable (OECD 2006).
The substance should therefore be classified as readily biodegradable
because >60% biodegradation was reached within 28 days (OECD 301D).
Biodegradation in water: biodegradable
Significant (65%) degradation was observed
in a Closed Bottle test utilising a test concentration of 2 mg/L. A
modified MITI test using a high test concentration of 100 mg/L resulted
in low biodegradability.
The higher degree of biodegradation
observed in tests with a lower initial test substance concentration
indicates limited bioavailability. It is possible that the rate of
biodegradation may be limited by the rate of hydrolysis of the test
substance and/or the rate with which the substance dissolves. Modelling
of possible biodegradation pathways indicate that aerobic degradation is
likely, the first steps in this being hydrolysis to trimellitic acid and
octanol, both of which have been shown to be readily biodegradable.
Tests with a structural analogue of
the substance, a trimellitate ester with mixed C8 -C10 side chains,
showed significant biodegradation and, while not readily biodegradable,
this analogue can be considered to be inherently biodegradable. The
differences observed in tests on the two substances may be a result of
methodology, particularly important when testing “difficult” substances
– in this case, substances with low water solubility.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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