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EC number: 219-372-2
CAS number: 2425-85-6
C.I Pigment Red 3 was tested for mutagenicity with the strains TA 100,
TA 1535, TA 1537 and TA 98 of Salmonella typhimurium.
The mutagenicity studies were conducted in the standard plate test (Ames
Test) and in a modified preincubation test (Prival Test). The studies
were performed in the absence and in the presence of a metabolizing
system derived from hamster liver homogenate. A dose range of 6
different doses from 4 microgram/plate to 5 000 microgram/plate was used
for the mutagenicity study. In a third independent experiment a dose
range of 7 different doses from 100 microgram/plate to 7 500
microgram/plate was used.
Control plates without mutagen showed that the number of spontaneous
revertant colonies was similar to that described in the 1iterature. All
the positive control compounds gave the expected increase in the number
of revertant colonies.
Toxicity: The test compound proved to be not toxic to the bacterial
strains. 5 000 microgram/plate was chosen as top dose level for the
a) Ames Test: Mutagenicity: In the absence of the metabolic activation
system the test com- pound did not show a dose dependent increase in the
number of revertants in any of the bacterial strains.
b) Prival Test: In the presence of hamster liver S-9 using the
preincubation method according to Prival C.I Pigment Red 3 induce a dose
dependent increase in the number of revertant colonies, with the tester
strain TA 1537.
Summarizing, it can be stated that C.I Pigment Red 3 is not mutagenic in
the standard plate test (Ames Test) but in the preincubation method to
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