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EC number: 219-372-2
CAS number: 2425-85-6
Testing for sensitizing properties of Pigment Red 3 was performed
in female Guinea pigs according to the method of Magnusson & Kligman.
Intra dermal induction was performed using 0.2% Pigment Red 2 in
semi-liquid paraffin. Dermal induction was carried out with 5%,
challenge treatment with 1% Pigment Red 3 in petrolatum.
Four animals of the treatment group showed a positive skin response
after the first challenge procedure and one animal reacted after the
second challange. If the effects observed at the first challange are due
to sensitization, then equal or even stronger reactions would be
expected after the second challenge procedure. Therefore, the reactions
noted in the three other animals at the first challange are considered
to be rather unspecific irritation effects than allergic reactions.
Based on the results of this study Pigment Red 3 is not considered
to be a skin sensitizer.
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