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Stability in organic solvents and identity of relevant degradation products

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Reference
Endpoint:
stability in organic solvents and identity of relevant degradation products
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10.December 2007
Reliability:
2 (reliable with restrictions)
Guideline:
other: Method agreed upon at the "Analytical Experts Meeting" of ETAD (Basel) on January 12, 2005
Principles of method if other than guideline:
The substance was suspended in water saturated octanol and shaken for 2 hours at 30 °C (+/-2°C). Then shaking was continued at ambient temperature for 70 hours followed by filtration. Quantification of the test substance was done by UV-vis spectrometry by applying the Lambert-Beer rule.
GLP compliance:
no
Specific details on test material used for the study:
The purity of the test material was >99,5%.
About 5 mg of the test sample were suspended in 30 ml water saturated octanol in a sample flask and were shaken for 2 hours at 30°C (+/- 2°C) on a "Büchi Syncore Polyvap" with 400 rpm. The shaking was continued at ambient temperature (22 - 23°C, determined) for 70 hours, followed by filtration through a 0.2µm membrane filter and then through two 0.2 µm membrane filters. A residue of undissolved colorant remained on the filter. No particles were noticed in the clear solution by visually check.
Test substance stable:
yes
Transformation products:
not measured
Conclusions:
Test substance is stable in organic solvents but has a low solubility
Executive summary:

The solubility of Pigment Red 3 in water saturated octanol at 22-23°C was determined to be 19.8 mg/l.The test substance is stable in organic solvents.

Description of key information

Pigment Red 3 is stable in organic solvents.

Additional information

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