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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1983
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
no
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(4-methyl-2-nitrophenylazo)-2-naphthol
EC Number:
219-372-2
EC Name:
1-(4-methyl-2-nitrophenylazo)-2-naphthol
Cas Number:
2425-85-6
Molecular formula:
C17H13N3O3
IUPAC Name:
1-(4-methyl-2-nitrophenylazo)-2-naphthol
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder

Test animals

Species:
rabbit
Strain:
other: Albino-Neuseeländer

Test system

Type of coverage:
semiocclusive
Preparation of test site:
clipped
Vehicle:
other: Polyethylenglycol 400
Duration of treatment / exposure:
4 hours
Observation period:
72 hours
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
72 h
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible within: 24 hours
Irritation parameter:
edema score
Basis:
mean
Time point:
72 h
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible within: 24 hours
Irritation parameter:
erythema score
Basis:
mean
Time point:
48 h
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible within: 24 hours
Irritation parameter:
edema score
Basis:
mean
Time point:
48 h
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible within: 24 hours
Irritation parameter:
erythema score
Basis:
mean
Time point:
24 h
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible within: 24 hours
Irritation parameter:
edema score
Basis:
mean
Time point:
24 h
Score:
ca. 0
Max. score:
0
Reversibility:
fully reversible within: 24 hours
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 1h
Score:
>= 0 - <= 1
Max. score:
0.1
Reversibility:
fully reversible within: 24 hours

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test material is not skin irritating or corrosive according to the study result