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EC number: 219-372-2
CAS number: 2425-85-6
2- Week Studies:
Groups of five rats and five mice of each Sex were given feed containing
0,6,000,12,500, 25,000, 50,000, or 100,000 ppm C.I. Pigment Red 3 for 2
weeks. No chemical-related deaths occurred in rats or mice. Final mean
body weights of exposed rats and male mice were lower than controls;
female mice that received 6,000 and 50,000 ppm had significantly
increased final mean body weights compared to that of the controls. The
feed consumption of treated rats and mice was slightly greater than that
of the controls, suggesting that C.I. Pigment Red 3 had no adverse
effects on the feed palatability. Dose-related decreases in erythrocyte
counts and hematocrit values and an increase in reticulocyte counts were
observed in rats. Changes in these Parameters were observed in mice, but
there were no clear, dose-related trends.
Groups of ten rats and ten mice of each Sex were given feed containing
0, 3,000, 6,000, 12,500, 25,000, or 50,000 ppm C.I. Pigment Red 3 for 13
dose levels selected were 0, 6000, 12500 and 25000 ppm. This resulted in
weighted average daily dose levels of 272, 567, and 1219 mg/kg b.w. in
males and 323, 686, and 1388 mg/kg in females at 6000, 12500 and 25000
ppm, respectively. No chemical-related deaths were observed in
rats or mice. The final mean body weights of exposed female rats were
significantly lower than that of the controls; the final mean body
weights of exposed male rats and exposed mice were similar to controls.
There were significant increases in relative liver and kidney weights of
exposed male rats. Increases in the relative liver weights in mice did
not occur with a dose-related trend and thus they were not considered
related to chemical administration. Sites for the toxicity of C.I.
Pigment Red 3 were the bone marrow, kidney, liver, and spleen in rats.
Lesions observed in rats included bone marrow hyperplasia, congestion
and hematopoietic cell proliferation of the spleen, and iron-positive
pigmentation of the spleen, kidney, and liver. Sites for the toxicity of
C.I. Pigment Red 3 in mice were the liver, kidney, and spleen in males
and the liver and spleen in females. Lesions noted among mice in the
spleen were hematopoietic cell proliferation and iron-positive
pigmentation. In the liver, there was hematopoietic cell proliferation
in male and female mice. Cytomegaly occurred in the renal tubule
epithelium of the male mouse kidney.
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