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EC number: 202-597-5
CAS number: 97-63-2
Mean Draize score
after 24 h
after 48 h
after 72 h
Conjunctiva redness (erythem) /Bindehautrötung[Scores]
Conjunctiva chemosis /Bindehautödem[Scores]
In an occular irritation test acc. the federal Hazardous
Substances and Labelling Act Regulations, Section 191.12 published in
the Federal Register - 29 F.R. 13009, 1964. Ethyl methacrylate (0.1 ml)
was placed in the conjunctival sac of the right eye of six New Zealand
White rabbits. The lids were then gently held together for one second.
The test eyes were not washed out following the instillation. The left
eye remained untreated for control. The eyes were examined at 1, 24, 48
and 72 hours. Eye irritation was scored for signs of corneal damage
(density, area), iris reaction and lesions of the conjunctivae
(erythema, chemosis). Additionally, the cornea was examined with the aid
of fluorescein after recording the observations at 24 hours. No
observation after 72 hrs. Scores were reevaluated acc. CLP criteria.
Highest mean cornea score (24+48+72 h) was 0.33 in 2/6 animals, no
animal showed iritis, 3/6 animals showed conjunctival erythema > 2 and
2/6 animals cunjunctival chemosis > 2. Scores showed clear tendency in
rapid reversibility but during the short observation time (72 h) full
reversibility could not be observed in all animals (scores in 2/6
animals were fully reversible).
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