Registration Dossier
Registration Dossier
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EC number: 202-597-5 | CAS number: 97-63-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- acceptable for assessment although with limited documentation
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Screening data pre-GLP and pre-guideline development, study details not reported in the publication.
- Reason / purpose for cross-reference:
- reference to same study
- Principles of method if other than guideline:
- pre-guideline development
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 1810, 2720, 3630, 4540, 5440 and 7260 mg/kg/bw
- No. of animals per sex per dose:
- 1 animal per dose
- Statistics:
- LD50-values calculated by the method of Bliss (1938).
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 720 mg/kg bw
- Mortality:
- Single rabbits survived doses of 1.81, 2.72 and 4.54 gram/kg. Single rabbits died at doses of 3.63, 5.44 and 7.26 g/kg.
- Clinical signs:
- other: Lethal doses produced a constant train of disturbances. The animals showed an increased rate of respiration (with lacrymation in rats) in about 2 to 5 minutes, followed by motor weakness and decreased respiration in 15 - 40 minutes. Subsequently, respi
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 941
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Pre-dates GLP and existing guidelines
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl methacrylate
- EC Number:
- 202-597-5
- EC Name:
- Ethyl methacrylate
- Cas Number:
- 97-63-2
- Molecular formula:
- C6H10O2
- IUPAC Name:
- ethyl methacrylate
- Details on test material:
- Purity: no data, without inhibitor usually added to prevent polymerization.
Supplier: Röhm & Haas Company, Philadelphia, Pennsylvania
Ethyl Methacrylate; sp. gravity: 0.907 at 20 degrees C;
B.Pt.: 117 degrees C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 12700, 14510, 16330 and 18140 mg/kg (single dose)
- No. of animals per sex per dose:
- 10 rats per dose
- Details on study design:
- Doses were given via stomach tube to test animals and observed to toxic symptoms and death.
- Statistics:
- LD50 for rats was calculated by the method of Bliss (1938), but was not reported.
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 13 424 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Original value LD50: 14.8 ml/kg = 13424 mg/kg
- Mortality:
- Deaths in rats were as follows: 3/10 (low dose), 8/10 (next dose), and 10/10 rats at the two highest doses. Rats died within 1-96 hours.
- Clinical signs:
- other: Author noted that both species exhibited increased respiratory rate and lacrimation within 2-5 minutes; followed by motor weakness and decreased respiration, increased defecation and urination in 15-40 minutes. Animals which did not survive, died in a com
Any other information on results incl. tables
The LD50 estimated by the method of Bliss clearly demonstrates that the test material is of low acute toxicity by the oral route.
Applicant's summary and conclusion
- Conclusions:
- A reliable published acute oral LD50 in rats was 13424 mg/kg bw.
- Executive summary:
A reliable published acute oral LD50 in rats was 13424 mg/kg bw.
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