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EC number: 203-815-1
CAS number: 110-91-8
In accordance with column 2 of REACH Annex
VII, a sensitisation study does not need to be conducted because the
substance is classified for skin corrosivity. Given as supplementary
information, no skin sensitization was seen in an animal study with
guinea pigs tested with a 2% solution of Morpholine.
sensitizing potential of Morpholine was tested on 10 guinea pigs by
Buehler's method. Morpholine (2 %in Vaseline) proved not to be skin
sensitizing. Thus, the Morpholine ring alone was incapable of inducing
sensitization. A positive reaction in animals sensitized to
4,4-'dithiodimorpholine was attributed by the authors to irritation in
morpholine is alkaline and is corrosive to skin and mucous membranes, a
sensitisation study does not need to be conducted in accordance with
column 2 of REACH Annex VII.
the sensitizing potential of morpholine was tested on 10 guinea pigs by
Buehler's method (Wang & Suskind, 1988). Morpholine (2 % in vaseline)
proved not to be skin sensitizing. In an in vitro experiment it was
investigated whether or not morpholine, being a haptene, reacts with
amino acids, thereby unfolding a sensitizing action. No reaction
occurred with either lysine, cysteine or glycine (Wang & Tabor, 1988).
There are no human data available indicating
a respiratory sensitisation potential.
Labeling, and Packaging Regulation (EC) No 1272/2008
is classified for skin corrosivity. Thus, in accordance with column 2 of
REACH Annex VII, a sensitisation study does not need to be conducted.
There are data available indicating no dermal sensitisation potential of
on this information, the test item is considered not to be classified
for skin sensitisation under Regulation (EC) No.1272/2008, as amended
for the fifteenth time in Regulation (EU) 2020/1182.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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