Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Since morpholine is alkaline and is corrosive to skin and mucous membranes, a sensitisation study does not need to be conducted in accordance with column 2 of REACH Annex VII.

However, the sensitizing potential of morpholine was tested on 10 guinea pigs by Buehler's method (Wang & Suskind, 1988). Morpholine (2 % in vaseline) proved not to be skin sensitizing. In an in vitro experiment with limited reliability it was investigated whether or not morpholine, being a haptene, reacts with amino acids, thereby unfolding a sensitizing action. No reaction occurred with either lysine, cysteine or glycine (Wang & Tabor, 1988).


Migrated from Short description of key information:
In accordance with column 2 of REACH Annex VII, a sensitisation study does not need to be conducted because the substance is classified for skin corrosivity. Given as supplementary information, no skin sensitization was seen in an animal study with guinea pigs tested with a 2% solution of morpholine.

Respiratory sensitisation

Endpoint conclusion
Additional information:

Migrated from Short description of key information:
There are no human data available indicating a respiratory sensitisation potential.

Justification for classification or non-classification

Classification, Labeling, and Packaging Regulation (EC) No 1272/2008

Morpholine is classified for skin corrosivity. Thus, in accordance with column 2 of REACH Annex VII, a sensitisation study does not need to be conducted. There are data available indicating no dermal sensitisation potential of Morpholine. Based on the results of the skin sensitisation study (no skin reactions after challenge with a 2% solution of test substance in vaseline), morpholine is not subject to classification as dermally sensitizing substance according to Regulation 1272/2008/EC.