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EC number: 240-367-6
CAS number: 16260-09-6
Nominal concentration (% v/v saturated solution)
Immobilized Daphnia (mean)
population: 5 per replicate)
there was no immobilization in 20 daphnids exposed to test
concentrations of 10, 18, 32 and 56% v/v saturated solution, 2 daphnia
were observed to be immobilized in the 100% v/v saturated solution test
concentration. However, as this is only 10% immobilization this is not
thought to be a true toxic effect of this test item. Inspection of the
immobilization data gave the following results:
Time (h) EC50 (% v/v saturated solution)
No Observed Effect Concentration after 24 and 48 hours exposure was 100%
v/v saturated solution.
No immobilisation or other negative effects were observed in any of the daphnids exposed to the test substances up to the highest attainable concentration tested. The substance is not harmful to aquatic invertebrates.
A study was performed to assess the
acute toxicity of the test item to Daphnia magna. The method
followed was designed to be compatible with the OECD Guidelines for
Testing of Chemicals (April 2004) No 202, "Daphnia sp.,
Acute Immobilisation Test" referenced as Method C.2 of Commission
Regulation (EC) No. 440/2008.The
test substance is highly insoluble in water and pre-study solubility
work conducted indicated that it was not possible to obtain a testable
solution of the test item using traditional methods of preparation e.g.
ultrasonication and high-shear mixing. A pre-study media preparation
trial indicated that the use of a saturated solution method of
preparation was most appropriate for this test item. The 48-Hour EC50
for the test item to Daphnia
magna based on nominal test concentrations was greater than 100% v/v
saturated solution. The No Observed Effect Concentration was 100% v/v
saturated solution. Chemical analysis of the test preparations at 0 and
48 hours showed measured test concentrations of less than the limit of
quantitation (LOQ) of the analytical method employed were obtained which
was determined to be 0.0141 mg/L.
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