(Z)-N-octadec-9-enylhexadecan-1-amide

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

13-Nov-2012 to 14-Mar-2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

not specified

Type of method:

column elution method

Key result

Water solubility:

< 0.01 mg/L

Conc. based on:

test mat.

Temp.:

20 °C

pH:

> 6.6 - < 6.8

Results

  

Flow rate (mL/h)	Fraction No.	Oleyl Palmitamide	pH value
25.0	1 (1-2)	< 0.01	6.7
	2 (3-4)	< 0.01	6.7
	3 (5-6)	< 0.01	6.8
	4 (7-8)	< 0.01	6.8
	5 (9-10)	< 0.01	6.8
	6 (11-12)	< 0.01	6.8
	7 (13-14)	< 0.01	6.8
	8 (15-16)	< 0.01	6.8
12.5	1 (1-2)	< 0.01	6.7
	2 (3-4)	< 0.01	6.7
	3 (5-6)	< 0.01	6.7
	4 (7-8)	< 0.01	6.7
	5 (9-10)	< 0.01	6.7
	6 (11-12)	< 0.01	6.7
	7 (13-14)	< 0.01	6.7
	8 (15-16)	< 0.01	6.7

 

 

Thus, the following value for water solubility of the test item Oleyl Palmitamide can be reported according to test procedure according to EU test method L142A/57-66 (EEC A.6).

 

Water solubility Oleyl Palmitamide < 0.01 mg/L

 

pH value HPLC water: 6.6

The water solubility was determined at 20 °C

Working range

The calibration curve fits over the whole working range from 0.01 to 2.06 mg/L with r²= 1. A quadratic fit was used.

 

Recovery

In the course of the recovery experiment, an average recovery rate of 117% was determined.

Conclusions:

Interpretation of results: insoluble (< 0.1 mg/L)

Description of key information

< 0.01 mg/L at 20 °C

Additional information

A water solubility value of < 0.01 mg/L at 20 °C was determined according to EU Method A.6.