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EC number: 240-367-6
CAS number: 16260-09-6
toxicity data for invertebrates and algae are available for
(Z)-N-Octadec-9-enylhexadecan-1-amide (CAS No. 16260-09-6). The test
substance is highly insoluble in water and no effects were observed to
aquatic algae and daphnia in the range of water solubility
of(Z)-N-Octadec-9-enylhexadecan-1-amide (CAS No. 16260-09-6).
for analogue approach of substances and read-across
with Article 13 (1) of Regulation (EC) No 1907/2006, "information on
intrinsic properties of substances may be generated by means other than
tests, provided that the conditions set out in Annex XI are met. In
particular for human toxicity, information shall be generated whenever
possible by means other than vertebrate animal tests", which includes
the use of information from structurally related substances (grouping or
Having regard to
the general rules for grouping of substances and read-across approach
laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006,
whereby substances may be considered as an analogue substances provided
that their physicochemical, toxicological and ecotoxicological
properties are likely to be similar or follow a regular pattern as a
result of structural similarity, the substances listed below are
structural similar related secondary fatty amides. In particular, for
each specific endpoint the source substance(s) structurally closest to
the target substance is chosen for read-across, with due regard to the
requirements of adequacy and reliability of the available data.
Structural similarities and similarities in properties and/or activities
of the source and target substance are the basis of read-across.
justification for analogue approach of chemicals and read-across is
provided in the technical dossier (see IUCLID Section 13).
from N-Octadecylstearamide (CAS No. 13276-08-9) to
(Z)-N-Octadec-9-enylhexadecan-1-amide (CAS No. 16260-09-6)
The target substance and the source
substance are amides of unsaturated or saturated fatty acids,
respectively. The target substance,
(Z)-N-octadec-9-enylhexadecan-1-amide (oleyl palmitamide, CAS
16260-09-6), and the source substance, N-octadecylstearamide (stearyl
stearamide, CAS 13276-08-9), are secondary N-alkyl alkylamides produced
from a coupling reaction between an appropriate fatty acid and a fatty
amine (March, 1992). It should be noted that the original raw materials
used for manufacture of the fatty amines are also similar (or the same)
fatty acids.For the following
endpoints, data from the related substance N-octadecylstearamide
(stearyl stearamide, CAS 13276-08-9)
will be used as read-across:
toxicity of N-octadecylstearamide (stearyl stearamide, CAS
13276-08-9)to fish was investigated in
one study according to EU Method C.1 and following GLP principles (Balk,
1989). In this limit test, guppies (Poecilia reticulata) were
exposed to a nominal concentration of 1000 mg/L under semi-static
Key physicochemical parameters and ectoxicological data for the
registered and surrogate substances.
(Z)-N-Octadec-9-enylhexadecan- 1-amide (CAS No. 16260-09-6)
N-Octadecylstearamide (CAS No. 13276-08-9)
Partition coefficient(log Kow)
Log Kow: > 5.7 at 23°C
Log Kow: 15.51 (QSAR)
Water solubility < 0.01 mg/L at 20°C and pH 6.6
Water solubility below 1 mg/L. (2.385E-011 mg/L, QSAR)
Not readily biodegradable: 42% (ThO2) after 30 days (OECD 301 D) and 27% (ThO2) after 42 days (DGXI/400/84)
Not readily biodegradable: 8-24 % after 28 days
Low bioaccumulation potential (BCF = 0.89 L/kg wet-wt, QSAR)
Low bioaccumulation potential (BCF = 3.16 L/kg wet-wt, QSAR)
Fish acute toxicity 96h LC50 mg/L
RA from stearyl stearamide: LC50 (96 h) > 1000 mg/L. No toxicity up to the limit of water solubility.
LC50 (96 h) > 1000 mg/L. No toxicity up to the limit of water solubility.
Daphnia acute toxicity 48h EC50 mg/L
No toxicity up to the limit of water solubility.
Long-term toxicity to fish
Long-term toxicity to aquatic invertebrates
Algae toxicity 72h EC50/NOEC mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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