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EC number: 240-367-6 | CAS number: 16260-09-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Short term toxicity data for invertebrates and algae are available for (Z)-N-Octadec-9-enylhexadecan-1-amide (CAS No. 16260-09-6). The test substance is highly insoluble in water and no effects were observed to aquatic algae and daphnia in the range of water solubility of(Z)-N-Octadec-9-enylhexadecan-1-amide (CAS No. 16260-09-6).
Justification for analogue approach of substances and read-across
In accordance with Article 13 (1) of Regulation (EC) No 1907/2006, "information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI are met. In particular for human toxicity, information shall be generated whenever possible by means other than vertebrate animal tests", which includes the use of information from structurally related substances (grouping or read-across).
Having regard to the general rules for grouping of substances and read-across approach laid down in Annex XI, Item 1.5, of Regulation (EC) No 1907/2006, whereby substances may be considered as an analogue substances provided that their physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity, the substances listed below are structural similar related secondary fatty amides. In particular, for each specific endpoint the source substance(s) structurally closest to the target substance is chosen for read-across, with due regard to the requirements of adequacy and reliability of the available data. Structural similarities and similarities in properties and/or activities of the source and target substance are the basis of read-across.
A detailed justification for analogue approach of chemicals and read-across is provided in the technical dossier (see IUCLID Section 13).
Read-across from N-Octadecylstearamide (CAS No. 13276-08-9) to (Z)-N-Octadec-9-enylhexadecan-1-amide (CAS No. 16260-09-6)
The target substance and the source substance are amides of unsaturated or saturated fatty acids, respectively. The target substance, (Z)-N-octadec-9-enylhexadecan-1-amide (oleyl palmitamide, CAS 16260-09-6), and the source substance, N-octadecylstearamide (stearyl stearamide, CAS 13276-08-9), are secondary N-alkyl alkylamides produced from a coupling reaction between an appropriate fatty acid and a fatty amine (March, 1992). It should be noted that the original raw materials used for manufacture of the fatty amines are also similar (or the same) fatty acids.For the following endpoints, data from the related substance N-octadecylstearamide (stearyl stearamide, CAS 13276-08-9) will be used as read-across:
The short-term toxicity of N-octadecylstearamide (stearyl stearamide, CAS 13276-08-9)to fish was investigated in one study according to EU Method C.1 and following GLP principles (Balk, 1989). In this limit test, guppies (Poecilia reticulata) were exposed to a nominal concentration of 1000 mg/L under semi-static conditions.
Key physicochemical parameters and ectoxicological data for the registered and surrogate substances.
Name/CAS # |
(Z)-N-Octadec-9-enylhexadecan- 1-amide (CAS No. 16260-09-6) |
N-Octadecylstearamide (CAS No. 13276-08-9) |
Partition coefficient(log Kow) |
Log Kow: > 5.7 at 23°C |
Log Kow: 15.51 (QSAR) |
Water solubility |
Water solubility < 0.01 mg/L at 20°C and pH 6.6 |
Water solubility below 1 mg/L. (2.385E-011 mg/L, QSAR)
|
Biodegradability |
Not readily biodegradable: 42% (ThO2) after 30 days (OECD 301 D) and 27% (ThO2) after 42 days (DGXI/400/84) |
Not readily biodegradable: 8-24 % after 28 days |
Bioaccumulation |
Low bioaccumulation potential (BCF = 0.89 L/kg wet-wt, QSAR) |
Low bioaccumulation potential (BCF = 3.16 L/kg wet-wt, QSAR) |
Fish acute toxicity 96h LC50 mg/L |
RA from stearyl stearamide: LC50 (96 h) > 1000 mg/L. No toxicity up to the limit of water solubility. |
LC50 (96 h) > 1000 mg/L. No toxicity up to the limit of water solubility. |
Daphnia acute toxicity 48h EC50 mg/L |
No toxicity up to the limit of water solubility. |
n/a |
Long-term toxicity to fish |
n/a |
n/a |
Long-term toxicity to aquatic invertebrates |
n/a |
n/a |
Algae toxicity 72h EC50/NOEC mg/L |
No toxicity up to the limit of water solubility. |
n/a |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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