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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the attached analogue justification provided in IUCLID Section 13.
Reason / purpose for cross-reference:
exposure-related information
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
>= 0.02 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
reproduction
Duration:
21 d
Dose descriptor:
NOEC
Effect conc.:
>= 0.02 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
mortality

Description of key information

No long term toxicity towards aquatic invertebrates based on read across from CAS 68583-51-7

Key value for chemical safety assessment

Additional information

No studies investigating the long-term toxicity to aquatic invertebrates of propylene dinonanoate (CAS 41395-83-9) are available. Since the substance bears low water solubility, long term data were taken into consideration for assessment. Thus in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to the structurally related substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was conducted. This read-across is justified in detail in the analogue justification in IUCLID section 13.

The study with the source substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was performed according to the OECD Guideline 211 under GLP conditions (2001). Daphnia magna was exposed to individually prepared Water Accommodated Fractions (WAF’s) of nominal 6.25, 12.5, 25, 50 and 100 mg/L under semi-static conditions. Analytical determination of test solution concentration resulted in very low concentrations of 0.03 mg/L in freshly prepared medium and concentrations below the detection limit of 0.01 mg/L before test medium renewal periods after every 48 or 72 h, respectively. After 21 d, no particular signs of intoxication, no mortality and no effects on the mean reproduction rate were observed throughout the test resulting in an EC50 (21 d) of > 0.02 mg/L (measured, arithm. mean) and a NOEC (21 d) of ≥ 0.02 mg/L (measured arithm. mean).

Based on the results from the structurally related read-across substance, which is characterized by a similar ecotoxicological profile, it can be concluded that propylene dinonanoate (CAS 41395-83-9) will not cause chronic effects to aquatic invertebrates up to the limit of water solubility.