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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

The hazard assessment is based on the data currently available. New studies with the registered substance and/or other member substances of the glycol esters category will be conducted in the future. The finalised studies will be included in the technical dossier as soon as they become available and the hazard assessment will be re-evaluated accordingly.

For further details, please refer to the category concept document attached to the category object (linked under IUCLID section 0.2) showing an overview of the strategy for all substances within the glycol esters category.

Key value for chemical safety assessment

Additional information

The hazard assessment is based on the data currently available. New studies with the registered substance and/or other member substances of the glycol esters category will be conducted in the future. The finalised studies will be included in the technical dossier as soon as they become available and the hazard assessment will be re-evaluated accordingly.

For further details, please refer to the category concept document attached to the category object (linked under IUCLID section 0.2) showing an overview of the strategy for all substances within the glycol esters category.

 

No studies investigating the long-term toxicity to aquatic invertebrates of propylene dinonanoate (CAS 41395-83-9) are available. Since the substance bears low water solubility, long term data were taken into consideration for assessment. Thus in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 a read across to the structurally related substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was conducted.

 

The study with the source substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was performed according to the OECD Guideline 211 under GLP conditions (2001). Daphnia magna was exposed to individually prepared Water Accommodated Fractions (WAF’s) of nominal 6.25, 12.5, 25, 50 and 100 mg/L under semi-static conditions. Analytical determination of test solution concentration resulted in very low concentrations of 0.03 mg/L in freshly prepared medium and concentrations below the detection limit of 0.01 mg/L before test medium renewal periods after every 48 or 72 h, respectively. After 21 d, no particular signs of intoxication, no mortality and no effects on the mean reproduction rate were observed throughout the test resulting in an EC50 (21 d) of > 0.02 mg/L (measured, arithm. mean) and a NOEC (21 d) of ≥ 0.02 mg/L (measured arithm. mean).

 

Based on the results from the structurally related read-across substance, which is characterized by a similar ecotoxicological profile, it can be concluded that propylene dinonanoate (CAS 41395-83-9) will not cause chronic effects to aquatic invertebrates up to the limit of water solubility.