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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the attached analogue justification provided in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Duration:
3 h
Dose descriptor:
EC10
Effect conc.:
> 1 099 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
> 1 099 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration

Description of key information

No toxicity towards aquatic microorganisms based on read across from CAS 853947-59-8

Key value for chemical safety assessment

Additional information

Data on the toxicity of propylene dinonanoate (CAS 41395-83-9) to microorganisms are not available. Therefore, read-across to the structurally related source substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substance is characterized by similar fatty acid chain lengths as well as alcohol components and is therefore considered as a suitable representative for the assessment of the short-term toxicity of the target substance to aquatic invertebrates. A detailed read-across justification is provided in the analogue justification in IUCLID section 13.

The study with the source substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was performed according to the EU Method C.11 (GLP) using domestic activated sludge as inoculum (1997). Five concentrations up to a maximum of 1099 mg/L were tested. After 3 h of incubation, no inhibition of the respiration rate was observed resulting in an EC10/50 > 1099 mg/L.

Furthermore the studies on the biodegradability of the substance according to internationally accepted guideline criteria showed that sewage treatment plant microorganisms biodegrade rapidly the substance. This supports the results of the read across substance.

Based on the results from a structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5), it can be concluded that propylene dinonanoate (CAS 41395-83-9) will not exhibit effects on the respiration rate of microorganisms.