Propylene dinonanoate

Short-term toxicity to aquatic invertebrates

Description of key information

The hazard assessment is based on the data currently available. New studies with the registered substance and/or other member substances of the glycol esters category will be conducted in the future. The finalised studies will be included in the technical dossier as soon as they become available and the hazard assessment will be re-evaluated accordingly.

For further details, please refer to the category concept document attached to the category object (linked under IUCLID section 0.2) showing an overview of the strategy for all substances within the glycol esters category.

Additional information

The hazard assessment is based on the data currently available. New studies with the registered substance and/or other member substances of the glycol esters category will be conducted in the future. The finalised studies will be included in the technical dossier as soon as they become available and the hazard assessment will be re-evaluated accordingly.

For further details, please refer to the category concept document attached to the category object (linked under IUCLID section 0.2) showing an overview of the strategy for all substances within the glycol esters category.

 

There is no study available, in which the short-term toxicity of propylene dinonanoate (CAS 41395-83-9) to aquatic invertebrates was investigated. Therefore, read-across to the structurally related source decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) and butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) was performed in accordance with Regulation (EC) No 1907/2006 Annex XI, 1.5. The source substances are characterized by similar fatty acid chain lengths as well as alcohol components and are therefore considered suitable representatives for the assessment of the short-term toxicity of the target substance to aquatic invertebrates.

 

All available studies with the source substances were performed according to appropriate EU guidelines and GLP.

 

One experimental study investigating the short-term toxicity of the source substance decanoic acid, mixed diesters with octanoic acid and propylene glycol (CAS 68583-51-7) to aquatic invertebrates is available (1995). It was performed according to EU Method C.2 (GLP) with Daphnia magna in a static exposure regime. The test species were exposed to a Water Accommodated Fraction (WAF) of 1000 mg/L (nominal) for 48 h. A DOC analysis of the WAF resulted in a test substance concentration of 2.4 mg/L (meas. geom. mean). Since no effects were observed after 48 h an EC50 of > 2.4 mg/L (meas. geom. mean) was derived.

 

A further study is available testing the short-term toxicity of the source substance butylene glycol dicaprylate / dicaprate (CAS 853947-59-8) to aquatic invertebrates according to EU Method C.2 and GLP (1997). Daphnia magna as the test organism was exposed in a limit test to 1000 mg test item/L (WAF) and a control for 48 h. The concentration of the stock solution was measured via TOC and was 2.2 mg/L (0 h). The recovery rate in the stability test was > 80% and the concentration after 48 and 72 h did not differ more than 20%. Therefore, the test substance was bioavailable throughout the test. No toxicity effects were recorded resulting in an EL50 (48 h) > 1000 mg/L (nominal, WAF).

 

All data with the source substances consistently showed no toxicity effects towards aquatic invertebrates up to the water solubility limit. Based on the structural and chemical similarity of the target and source substances, the target substance is expected to exhibit a similar ecotoxicological profile. Therefore, it can be concluded that propylene dinonanoate (CAS 41395-83-9) will not cause short-term effects to aquatic invertebrates up to the limit of water solubility.