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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
No purity of test substance reported.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not applicable
Principles of method if other than guideline:
Study was conducted prior to adoption of any OECD guideline.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Propylene dinonanoate
EC Number:
255-350-9
EC Name:
Propylene dinonanoate
Cas Number:
41395-83-9
Molecular formula:
C21H40O4
IUPAC Name:
1-(nonanoyloxy)propan-2-yl nonanoate

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Fasting period before study: yes, 20-24 h
- Housing: 2-5 per cage

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Details on oral exposure:
The test material was administered as supplied by the sponsor.
Doses:
Preliminary test: 1000, 5000, 10000 mg/kg bw
Main test: 10000, 15000, 20000 mg/kg bw
No. of animals per sex per dose:
Preliminary test: 2 at 1000 mg/kg bw, 1 at 5000 and 1 at 10000 mg/kg bw
Main test: 5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
Statistics:
Probit method

Results and discussion

Preliminary study:
2m+2f animals at 1000 mg/kg: no mortality
1m+1f animal at 5000 mg/kg: no mortality
1m+1f animal at 10000 mg/kg: no mortality
Effect levelsopen allclose all
Key result
Sex:
male/female
Dose descriptor:
LD50
Remarks:
rat
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Key result
Sex:
male/female
Dose descriptor:
LD50
Remarks:
rat
Effect level:
16 025 mg/kg bw
Based on:
test mat.
Remarks:
Calculated using Probit method
95% CL:
> 12 973 - < 19 795
Remarks on result:
other:
Remarks:
5 out of 10 animals were dead after 14d observation period after single oral dosing at 15000 mg/kg
Mortality:
1 out of 10 rats was found dead after dosing at 10000 mg/kg. No mortality was seen in the preliminary study.

Any other information on results incl. tables

Dose
mg/kg

Gender

Total number of rats

Number of dead rats after 14 day observation period

% mortality

1000

m

2

0

0

1000

f

2

0

0

5000

m

1

0

0

5000

f

1

0

0

10000

m

1

0

0

10000

f

1

0

0

10000

m

5

1

10

10000

f

5

0

0

15000

m

5

4

80

15000

f

5

1

20

20000

m

5

4

80

20000

f

4

2

50

Applicant's summary and conclusion

Interpretation of results:
other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.