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EC number: 265-191-7
CAS number: 64742-88-7
A complex combination of hydrocarbons obtained from the distillation of crude oil or natural gasoline. It consists predominantly of saturated hydrocarbons having carbon numbers predominantly in the range of C9 through C12 and boiling in the range of approximately 140°C to 220°C (284°F to 428°F).
scores after the challenge treatment are summarised below
Response Grade Range
F-133 Induction/Challenge group
F-133 Challenge control
DNCB Induction/Challenge positive control
DNCB Challenge control
the basis of the above response, the test material was not sensitizing.
1 Scores: 9 out of 10 (test group); dose: 0.5 ml of undiluted F-133
1 Scores: 9 out of 10 (positive control); dose: 0.5 ml of 0.3% DNCB
2 Scores: 10 out of 10 (test group); dose: 0.5 ml of undiluted F-133
2 Scores: 10 out of 10 (positive control); dose: 0.5 ml of 0.3% DNCB
3 Scores: 10 out of 10 (test group); dose: 0.5 ml of undiluted F-133
3 Scores: 10 out of 10 (positive control); dose: 0.5 ml of 0.3% DNCB
0 out of
10 (Induction/Challenge test group); dose: 0.5 ml of F-133 1:4 dilution
in mineral oil
0 out of 4
(F-133 Challenge Control); dose: 0.5 ml of F-133 1:4 dilution in mineral
10 out of
10 (DNCB Induction/Challenge Group); dose: 0.5 ml of 0.3% DNCB in 80%
3 out of 4
(DNCB Challenge Control); dose: 0.5 ml of 0.2% DNCB in 80% ethanol
0 out of 4
(Vehicle Challenge Control); dose: 0.5 ml of mineral oil
In a dermal sensitisation study using
thermocracked kerosine in mineral oil, male young adult Pig/Hartley
guinea pigs were tested using a modified Buehler technique.
During the challenge phase, a second
exposure of a 1:4 dilution of thermocracked kerosine to induction test
animals did not yield higher response grades, severity, or incidence
than those associated with the naive challenge control group exposed to
thermocracked kerosine. During the challenge phase, exposure of 0.2%
DNCB to induction positive control animals elicited significantly higher
response grades, severity indices, and incidence over the naive DNCB
challenge control group. The vehicle irritation control group was free
of dermal irritation during the challenge phase. Therefore, under the
conditions of this study, thermocracked kerosine is not considered a
delayed contact sensitiser and DNCB induced an appropriate positive
This study received a Klimisch score of 1
and is classified as reliable without restriction because it was
conducted according to EPA OTS 798.4100.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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