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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1994

Materials and methods

Objective of study:
absorption
Principles of method if other than guideline:
Test guideline is unknown
GLP compliance:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
IUCLID4 Test substance: other TS: Blend of straight run hydrotreated kerosine (30%) and hydrocracked kerosine (70%)

Test animals

Species:
mouse

Administration / exposure

Route of administration:
dermal
Vehicle:
other: mineral oil
Duration and frequency of treatment / exposure:
96 hour(s)
Doses / concentrations
Remarks:
Doses / Concentrations:
Males: 15 µl undiluted and 60 µl diluted to 25% with mineral oil
No. of animals per sex per dose:
Males: 5

Results and discussion

Toxicokinetic / pharmacokinetic studies

Toxicokinetic parametersopen allclose all
Toxicokinetic parameters:
half-life 1st:
Toxicokinetic parameters:
half-life 2nd:
Toxicokinetic parameters:
half-life 3rd:

Any other information on results incl. tables

In the study with dermally applied undiluted test material approximately 5% of the labelled tetradecane and 15% of the labelled naphthalene was absorbed over 96 hours.
In the study with the 25% concentration of test material, approximately
 7% of the labelled tetradecane and 16% of the labelled naphthalene was absorbed over 96 hours.

In the passive inhalation study approximately 2.8% (undiluted test
 material) and 1.8% (25% concentration) of the labelled naphthalene was available.  In contrast, approximately 0.2% of labelled tetradecane in undiluted and diluted test material was absorbed.

These studies demonstrate that dilution of the test material in mineral
 oil did not influence absorption of the radiolabelled "spikes" present.

Applicant's summary and conclusion