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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
A reputable corporate laboratory utilized a standard protocol at a time when reporting of minimal data was routine. Only basic data is provided in this report. Due to the corrosive nature of the substance, consideration of repeating this study is inappropriate.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1983

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
No information provided, other than that the test was performed according to a standardized protocol for this corporate toxicology laboratory.
GLP compliance:
no
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-vinylpyridine
EC Number:
202-879-8
EC Name:
2-vinylpyridine
Cas Number:
100-69-6
Molecular formula:
C7H7N
IUPAC Name:
2-ethenylpyridine
Details on test material:
Test material = 98.95% pure

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
10 animals/ no sex stated

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Vehicle:
unchanged (no vehicle)
Concentration / amount:
No information was provided. Doses used in other dermal testing procedures within this report range from 5.0 to 0.2 ml/kg undiluted 2VP.
Challengeopen allclose all
Vehicle:
unchanged (no vehicle)
Concentration / amount:
No information was provided. Doses used in other dermal testing procedures within this report range from 5.0 to 0.2 ml/kg undiluted 2VP.
No. of animals per dose:
10 animals per dose
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

No. of animals per dose:
10
Statistics:
No information provided

Results and discussion

Any other information on results incl. tables

Sensitization responses:

2/10 animals showed no response

3/10 showed weak response

4/10 showed moderate response

1/10 showed potent response

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information
Conclusions:
In a standardized skin sensitization test in guinea pigs, this compound elicited reactions indicating a moderate risk for human sensitization.
Executive summary:

In a standard protocol used by a corporate toxicology testing laboratory, the dermal sensitization of 2 -VP was investigated. In 10 guinea pigs, there was a moderate risk of sensitization. While the information provided in this study is minimal, a classification of "sensitizing" is accepted, and the corrosive nature of 2VP precludes the need to repeat sensitization studies.