2-vinylpyridine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

May, 1994

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Guideline study for transportation classification. There is limited information on purity of the test material, but this was material meeting the specifications and characteristics of material shipped.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1994

Report date:

1994

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: DOT, Federal Register, 49 CFR, Subpart D, 173.136-137

Deviations:

no

Principles of method if other than guideline:

Test material is applied to the trunks of shaved New Zealand white rabbits under occlusive conditions for 1 hour. The test material was gently wiped off the skin. Test sites were evaluated again at 48 hours and scored for edema, eschar, necrosis.

GLP compliance:

no

Remarks:

but meeting internal laboratory quality criteria

Test material

Test material information

Constituent 1

Reference substance name:

2-vinylpyridine

EC Number:

202-879-8

EC Name:

2-vinylpyridine

Cas Number:

100-69-6

Molecular formula:

C7H7N

IUPAC Name:

2-ethenylpyridine

Details on test material:

2-Vinylpyridine, Lot # 40310AA, a clear amber liquid.

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.5 ml

Duration of treatment / exposure:

1 hour

Observation period:

1 hour and 48 hours

Number of animals:

6

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 48 hours

Reversibility:

not reversible

Remarks on result:

other: All 6 animals displayed skin necrosis at 48 hours.

Irritant / corrosive response data:

All 6 animals displayed eschar and irreversible alteration of the tissue evidenced by ulceration and necrosis

Other effects:

Skin was discolored purple at the site of test material administration

Any other information on results incl. tables

Positive for corrosion after a 1 hour exposure.

Applicant's summary and conclusion

Interpretation of results:

Category 1B (corrosive)

Remarks:

Migrated information Criteria used for interpretation of results: other: U.S. Department of Transportation

Conclusions:

2 -Vinylpyridine is corrosive to the skin of rabbits after a 1 hour exposure. The U.S. DOT classification is Class 8, Packing Group II. GHS Category 1B.