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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
basic toxicokinetics
Type of information:
other: review of existing literature
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: This review of toxicokinetics is reliable as it accounts for all the relevant available data in the published and unpublished literature.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010

Materials and methods

Objective of study:
other: Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information.
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Studies and publications were provided to a qualified toxicologist who reviewed the relevant available information and provided an assessment of the likely toxicokinetic behaviour of the substance.
GLP compliance:
no
Remarks:
not required

Test material

Constituent 1
Chemical structure
Reference substance name:
2-vinylpyridine
EC Number:
202-879-8
EC Name:
2-vinylpyridine
Cas Number:
100-69-6
Molecular formula:
C7H7N
IUPAC Name:
2-ethenylpyridine
Radiolabelling:
no

Results and discussion

Main ADME resultsopen allclose all
Type:
absorption
Results:
Small molecular weight, high water solubility and low octanol/water partition coefficient indicate that the substance is likely to be absorbed in the GI tract and via the skin.
Type:
distribution
Results:
Small molecular weight and high water solubility indicate that the substance is likely to be distributed in into the water compartment of the body. Skin sensitisation results suggest that the substance can bind to proteins in the blood.
Type:
metabolism
Results:
Small molecular weight and lack of microbial biodegradation suggest that metabolism may not be necessary to allow excretion from the body.
Type:
excretion
Results:
Excretion via the kidney is likely significant due to high water solubility and small molecular weight. Any substance which is not absorbed via the GI tract will be excreted in the faeces.

Metabolite characterisation studies

Metabolites identified:
no

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
Assessment of the toxicokinetic behaviour of 2VP was undertaken to the extent that can be derived from the relevant available information. Critical data include is small molecular weight, high water solubility and low octanol/water partitioning. These data suggest that 2VP is likely to be absorbed via the gastrointestinal tract, distributed in the water compartment of the body, and excreted via the kidneys with or without metabolism. Bioaccumulation and deposition in fat or breast milk is not likely.