2-vinylpyridine

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was undertaken in a corporate laboratory according to a standardized protocol, at a time when reporting of minimal data was routine. Only basic data is provided in this report.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1983

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Test material was instilled into the eyes of rabbits , and observations made on the effect on the eye. Fluorescein stain was applied to the eye to detect corneal damage.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-vinylpyridine

EC Number:

202-879-8

EC Name:

2-vinylpyridine

Cas Number:

100-69-6

Molecular formula:

C7H7N

IUPAC Name:

2-ethenylpyridine

Details on test material:

test material = 98.95% pure

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Details on test animals or tissues and environmental conditions:

3 animals per test/ sex not indicated

Test system

Vehicle:

unchanged (no vehicle)

Duration of treatment / exposure:

no information

Observation period (in vivo):

no information

Number of animals or in vitro replicates:

3 animals per test (washed and unwashed eyes)

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

other: 24 hours

Score:

3

Reversibility:

not fully reversible within:

Irritant / corrosive response data:

Strong eye irritant in unwashed eyes; moderate eye irritant in washed eyes.

Any other information on results incl. tables

unwashed eyes: 3/3 showed strong irritation

washed eyes: 3/3 showed moderate irritation

Corneal and adnexal staining of fluorescein in all washed and unwashed eyes. Prompt irrigation with distilled water was pallative.

Applicant's summary and conclusion

Interpretation of results:

Category I

Remarks:

Migrated information Corneal opacity but there is no qualitative score Criteria used for interpretation of results: EU

Conclusions:

Rabbit eye irritation was strong in unwashed (3/3) and moderate (3/3) in washed eyes; there was corneal and adnexal staining of fluorescein in all washed and unwashed eyes. Prompt irrigation with distilled water was palliative. 2VP is considered a severe eye irritant. While only minimal data is reported, consideration of repeating this study is inappropriate, due to the corrosive nature of the substance, and acceptance of a Category 1 classification.