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EC number: 429-330-7
CAS number: -
Assessment of acute dermal toxicity with
PDTN in the rat.
The study was carried out based on the
guidelines described in: EC Comm Directive 92/691EEC, Part B.3 and OECD
No.402. PDTN was administered to five Wistar rats of each sex by dermal
occlusive application at 2000 mglkg body weight for 24 hours. Animals
were subjected to daily
observations and weekly determination of
body weight. Macroscopic examination was performed after terminal
sacrifice (day 15; day 1 is day of dosing). No mortality occurred. Red
staining of the neck was noted in one female between days 3 and 7. Scabs
or scales were seen in the treated skin-area of two other females
between days 3 and 6. Body weight gain during the observation period was
slight in male rats and almost absent in female rats. If animals indeed
would have been ca. 9 weeks at the start of the study, the slight BW
gain in males or absence of BW gain in
females would point at a toxicological
relevant effect. However, based on the reported BW weights at the start
of the study it is more likely that animals of this strain (Wistar) were
much older and were, therefore, out of their growing phase.
No abnormalities were found at macroscopic
post mortem examination of the animals. The dermal LD50 value of PDTN in
Wistar rats was established as exceeding 2000 mg/kg body weight. Based
on these results and according to the OECD-GHS criteria for
classification, PDTN requires classification in Category V, as toxicity
at (much) higher levels was not tested.
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