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EC number: 429-330-7
CAS number: 110057-45-9
PDTN was tested in the Salmonella typhimurium
reverse mutation assay with four
histidine-requiring strains of Salmonella typhimurium (TA1535, TA1537,
TA100 and TA98) and in the Escherichia coli reverse mutation assay with
a tryptophan-requiring strain of Escherichia coli WP2uvrA in two
independent experiments. PDTN was tested up to concentrations of 5000
µg/plate both in the absence and presence of S9 -mix. PDTN did not
induce a dose-related increase in the number of revertant (His+)
colonies in each of the four tester strains (TA1535, TA1537, TA98 and
TA100) and in the number of revertant (Trp+) colonies in tester strain
WP2uvrA both in the absence and presence of S9 -metabolic activation.
These results were confirmed in an independently repeated experiment.
Based on the results of this study it is concluded that PDTN is not
mutagenic in the Salmonella typhimurium reverse mutation assay and in
the Escherichia coli reverse mutation assay.
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