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EC number: 429-330-7
CAS number: -
purpose of this study was to assess the toxicity of the test substance
dissolved in fresh water, on the reproductive efficacy of Daphnia
magna STRAUS - clone 5, in a semi-static test complying with the
OECD Guideline No. 211, 21st September 1998and
EU guideline C.20 from Annex V of Directive 67/548/EEC.
The test criterion of toxicity used
was reproductive capacity expressed as the number of neonates per
daphnid per day.
The nominal concentrations used in the
study were as follows: 0, 10, 32, 102.4, 327.7 and 1049 mg/L
All concentrations given refer to the
technical product as supplied by the sponsor.
Analytical determinations of the test
solutions were made on 13 occasions during the test. The concentrations
were found to remain within 80 and 120% of the nominals for 32 to 1049
mg/L. Only 10 mg/L was measured higher on average than 120%. This was
due to the intercept of the calibration curves used to calculate the
concentrations measured. All calibration curves had an intercept between
0.88 to 4.19 mg/L. On lower test concentrations this intercept has an
increasing effect as test concentrations are lower. As all other
concentrations measured are close to the nominals the effect data are
based on the nominal test concentrations.
The validity criteria were respected:
No mortality occurred in the control
group over the test period.
The average number of juveniles per
parent in the control was 63 after 22 days.
Normally, the No Observed Effect
Concentration (NOEC) is determined as the concentration used in the
study that is immediately below the Lowest Observed Effect Concentration
(LOEC), the latter derived statistically from the data using the
appropriate statistical test.
Reproduction and parental weight were
found to be the most sensitive endpoints.
These data was found to be normally
distributed and homogeneous. Using Dunnett’s and Bonferroni-t tests, the
lowest Observed Effect Concentration (LOEC) was found to be 32 mg/L.
Based on these statistical results the NOEC is 10 mg/L. An EC10and
EC50for reproduction were determined as well they were 25.6
mg/L and 51.0 mg/L, respectively.
The EC50for parent survival
was 148.6 mg/L.
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