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EC number: 619-437-9
CAS number: 99474-22-3
This GLP-compliant study was performed to
assess the potential of the test material to induce eye irritation in
vivo, according to OECD Guideline 405 (dated February 24th, 1987) and EU
method B.5 of the E.E.C. directive n° 92/69 (dated December 29th, 1992).
Material and methods
0.1 g of the test material were instilled as
supplied, into one eye of each of the 3 male rabbits, the other eye
untreated serving as control. Ocular examinations were performed on both
right and left eyes 1 hour and then 24, 48 and 72 hours after
instillation. An additional reading was performed 5 days after
administration. At the end of this period, the observations were ended.
Ocular reactions were observed during the
study but were all fully reversed 5 days after the administration of the
test material. The individual mean scores (24, 48 and 72 hours) were as
follows for cornea opacity: 0.33, 0.33 and 0.00, for iris: 0.00, 0.00
and 0.00, for conjunctivae: 0.67, 0.33 and 1.00 and for chemosis: 0.33,
0.00 and 0.00.
Under the experimental conditions of this
study, the test material is not classified as irritating to the eye
according to the Regulation (EC) No 1272/2008 on classification,
labelling and packaging (CLP) and the Globally Harmonized System of
Classification and Labelling of Chemicals (GHS) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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