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EC number: 619-437-9
CAS number: 99474-22-3
This GLP-compliant study was performed to
assess the acute oral toxicity of the test material, according to OECD
Guideline 401 (dated February 24th, 1987) and EU method B.1 of the
E.E.C. directive n°92/69 (dated December 29th, 1992).
Material and methods
The test material -suspended in 0.2% sodium
carboxymethyl cellulose and 10% Tween 80- was administered by gavage to
a group of 10 Sprague Dawley rats (5 males and 5 females) at a single
dose of 2000 mg/kg body weight. Animals were monitored at least 2 times
a day for 14 days. All rats were weighted before administration,
half-way through the observation period and before sacrifice. Necropsies
were performed on all the animals.
No mortalities or notable clinical signs
were recorded during the study. The evolution of the bodyweights was
normal throughout the study. The macroscopic examination of the animals
at the end of the study did not reveal any treatment-related change.
Under the experimental conditions of this
study, the oral LD50 of the test material is higher than 2000 mg/kg body
weight without mortality, clinical signs or macroscopic findings. Thus,
the test material is not classified as hazardous for acute oral toxicity
according to the Regulation (EC) No 1272/2008 on classification,
labelling and packaging (CLP) and the Globally Harmonized System of
Classification and Labelling of Chemicals (GHS) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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