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EC number: 619-437-9 | CAS number: 99474-22-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://www.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_physical-and-chemical-properties.png)
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15/05/2017 - 07/07/2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Version / remarks:
- adopted 23/03/2006
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Version / remarks:
- 24/08/2009
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
Test material
- Reference substance name:
- Pyrrolidine, 1-[2-[2-nitro-4-(phenylmethoxy)phenyl]ethenyl]-
- Cas Number:
- 99474-22-3
- Molecular formula:
- C19H20N2O3
- IUPAC Name:
- Pyrrolidine, 1-[2-[2-nitro-4-(phenylmethoxy)phenyl]ethenyl]-
Constituent 1
- Specific details on test material used for the study:
- - Analytical purity: > 98.4%
- Lot/batch No.: 0159115
- Expiration date of the lot/batch: 21/02/2018
Results and discussion
Vapour pressureopen allclose all
- Key result
- Temp.:
- ca. 20 °C
- Vapour pressure:
- ca. 0 Pa
- Remarks on result:
- other: calculated from the regression equation
- Key result
- Temp.:
- ca. 25 °C
- Vapour pressure:
- ca. 0 Pa
- Remarks on result:
- other: Calculated from the regression equation
- Temp.:
- ca. 75 °C
- Vapour pressure:
- ca. 0 Pa
- Remarks on result:
- other: experimental result
- Temp.:
- ca. 90 °C
- Vapour pressure:
- ca. 0.002 Pa
- Remarks on result:
- other: experimental result
- Temp.:
- ca. 105 °C
- Vapour pressure:
- ca. 0.012 Pa
- Remarks on result:
- other: experimental value
Transition / decomposition
- Key result
- Transition / decomposition:
- no
Any other information on results incl. tables
Observations
75°C. At the first measurement of experiment 4, all cells were slightly contaminated. Therefore, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.
90°C. At the second measurement of experiment 5, all cells showed no weight loss. On the basis of the first and third measurement the second measurement was defined as outlier. To avoid bias, this measurement was not used for calculations.
105°C. At the first, second and third measurement of experiment 6, cell 1 and 3 were slightly contaminated. Therefore, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, this measurement was not used for calculations.
150°C. At the first measurement of experiment 9, all cells were empty.
Evaluation
The measured values for temperature and vapour pressure were evaluated as follows:
Parameter |
T |
Mean P |
1/T |
log P |
Unit |
K |
Pa |
1/K |
log Pa |
Values |
348.2 |
4.55E-04 |
2.8719E-03 |
-3.3415 |
363.2 |
2.46E-03 |
2.7533E-03 |
-2.6095 |
|
378.2 |
1.19E-02 |
2.6441E-03 |
-1.9239 |
A graph with log P vs. 1/T was plotted. Since the values were correlated by a linear relation, the data could be fitted by linear regression.
Parameters of Linear Regression
Parameter |
Value |
Slope |
-6222.3 |
Intercept |
14.5265 |
CorrelationCoefficient r |
-1.0000 |
Coefficient ofDeterminationr2 |
1.0000 |
Results
Test Item
The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):
Experimentally Determined Vapour Pressures
T |
T |
P |
Stand. Dev. P |
RSD P |
°C |
K |
Pa |
Pa |
% |
75.0 |
348.2 |
4.55E-04 |
9.47E-05 |
20.8% |
90.0 |
363.2 |
2.46E-03 |
4.76E-04 |
19.4% |
105.0 |
378.2 |
1.19E-02 |
2.83E-03 |
23.8% |
Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation
For the test item, the following vapour pressures at 20°C and at 25°C were calculated from the regression equation:
Vapour pressure at 20°C: |
2.00* 10-07Pa |
Vapour pressure at 25°C: |
4.54* 10-07Pa |
The linear regression of log P vs. 1/T gave a correlation coefficient r of - 1.0000, showing good repeatability and precision. Therefore, the determination is considered as valid.
Positive Control
Vapour pressure (positive control) at 30°C: |
2.03*10-1Pa |
Criteria for thevapourpressure of the positive control at 30°C |
1.44*10-1± 0.1Pa |
The vapour pressure met the validity criteria. Therefore the study can be considered as valid.
Applicant's summary and conclusion
- Conclusions:
- For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
- Vapour pressure at 20°C: 2.00E-07 Pa
- Vapour pressure at 25°C: 4.54E-07 Pa - Executive summary:
The vapour pressure of the test item was determined according to OECD 104 resp. EU A.4 using the effusion method (weight loss; GLP study).
Vapour pressure was examined ateight different temperatures. Three temperatures could be evaluated as they showed reproducible weight loss. For these temperatures, 1/T was plotted against log (P).
Experiment
T
MeanP
Stand. Dev. P
RSD P
No.
K
Pa
Pa
%
4
348.2
4.55E-04
9.47E-05
20.8%
5
363.2
2.46E-03
4.76E-04
19.4%
6
378.2
1.19E-02
2.83E-03
23.8%
Stand. Dev. = Standard Deviation; RSD = Relative Standard Deviation
The graph 1/T vs. log (P) shows a straight line with a correlation coefficient of - 1.0000.
For the test item, the following vapour pressures at 20 °C and at 25 °C were calculated from the regression equation:
- Vapour pressure at 20°C: 2.00E-07 Pa
- Vapour pressure at 25°C: 4.54E-07 Pa
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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