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EC number: 619-437-9
CAS number: 99474-22-3
This GLP-compliant study was performed to
assess the potential of the test material to induce skin irritation in
vivo, according to OECD Guideline 404 (dated July 17th, 1992) and EU
method B.4 of the E.E.C. directive n° 92/69 (dated December 29th, 1992).
Material and methods
0.5 g of the solid test material were
applied under semi-occlusive dressing during 4 hours, on a shaved skin
area of 3 male rabbits. Skin reactions were recorded 1 hour and then 24,
48 and 72 hours after the end of the exposure period.
1 hour after the patch removal, very slight
erythema (grade 1) was observed in two animals. No dermal lesions were
observed in any animal at all the other observation time points. The
individual mean scores (24, 48 and 72 hours) of all three animals for
erythema and edema were both: 0.0, 0.0 and 0.0.
Under the experimental conditions of this
study, the test material is not classified as irritating to the skin
according to the Regulation (EC) No 1272/2008 on classification,
labelling and packaging (CLP) and the Globally Harmonized System of
Classification and Labelling of Chemicals (GHS) criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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