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EC number: 207-079-2
CAS number: 431-89-0
Animal studies show that 1,1,1,2,3,3,3-heptafluoropropane (HFC 227ea) has low acute inhalational toxicity.
In accordance with
section 2 of REACH Annex XI, an acute oral and dermal toxicity study do
not need to be conducted as the substance is a gas.
inhalation toxicity studies with 1,1,1,2,3,3,3 -heptafluoropropane
indicate that the acute inhalation toxicity study is low.
In the key study (WIL
Research Laboratories, 1992) no mortality was observed and a 4 h-LC50 >
788696 ppm (5483776 mg/m3) was
established. At this concentration, only transient signs of anaesthesia
during the exposure period and a decreased body weight and body weight
gain at the end of the 14 -day observation period were
Based on 4 h LC50 of > 788696
ppm (5,483,776 mg/m3) in
rats in a reliable OECD guideline study, 1,1,1,2,3,3,3
-heptafluoropropane does not have to be classified for acute toxicity in
accordance with EU
Directive 67/548/EEC and EU Classification, Labeling and Packaging of
Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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