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EC number: 207-079-2
CAS number: 431-89-0
No aquatic toxicity tests are available for HFC 227ea in fish,
invertebrates and/or algae. However, data is available from
GLP-compliant OECD guideline studies with the structurally similar
substances HFC 365mfc and HFC 245fa.
The aquatic PNECs were estimated by considering the lowest value
obtained for structural analogues (LC50 > 100 mg/l for HFC 245fa in
fish) and dividing it for the default assessment factors of 1000 for
freshwater and 100 for intermittent release. As the POD is not
indicative of a real LC50, derived PNECs can be considered as very
The analogue approach for the HFC category is justified and documented
in the position paper "Use if categories approach in environmental
hazard assessment of hydrofluorocarbons (HFCs) and
hydrochlorofluorocarbons (HCFCs)", attached in the Endpoint Summary in
Section 6 of the Technical Dossier (Ecotoxicological Information).
Toxicity to micro-organisms is determined according to an OECD 209
test. The 3-h EC50 of 173.1 mg/L in activated sludge (Voelskow, 1992)
will be used in the assessment.
Sediment toxicity: PNEC was estimated via the Equilibrium partitioning
method (Guidance IR&CSA, R.10). The Koc of 90.2 L/Kg estimated was used
for the estimation of the sediment-water partition coefficient Kp-sed in
Kp-sed= 0.05 * Koc = 4.51 L/Kg
Ksed-water was calculated in the equation:
Ksed-water = Fwater-sed + F soil-sed * (Kp-sed*2.5) = 0.8 + 0.2 *
(4.51*2.5) = 3.06
and used for the PNEC estimation in the equation:
PNECsed = (Ksed-water/1.15) * PNECwater = 0.27 mg/kg w.wt. for fresh
water. This PNEC can be converted to the values for dry weight sediment,
by dividing for the fraction of solid in the sediments (0.2), to give
the reported PNEC.
Terrestrial toxicity: No direct or indirect exposure to HFC 227ea is
expected for terrestrial organisms. No PNEC derivation is necessary.
Oral (secondary poisoning): due to the very low bioaccumulation
potential of HFC 227ea, no secondary poisoning is to be expected. PNEC
derivation is not necessary.
No data are available for HFC 227ea. However, the comparison with other
structurally related HFCs showed that no aquatic acute ecotoxicity is to
be expected at concentrations ≤ 100 mg/l. Besides, due to the
environmental behaviour of those substances, a very low partitioning
into the aquatic environment is predictable. Based on all available data
on structural analogues for daphnids, fish and algae, HFC 227ea is not
classifiable as hazardous to the aquatic environment. As HFC 227ea does
not contain Chlorine or Bromine, it is not classifiable as dangerous for
the ozone layer. In conclusion, no classification for environmental
endpoints is deemed necessary for HFC 227ea under Directive 67/548/EEC
and Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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