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EC number: 207-079-2
CAS number: 431-89-0
The results of a cardiac sensitisation study in the dog showed the substance to be capable of sensitising the heart to the effects of adrenalin at concentrations from 9% onwards.
An available acute cardiac sensitisation
study with dogs (WIL Research Laboratories, Inc., 1993b) indicated that
1,1,1,2,3,3,3-heptafluoropropane causes a sensitisation (specifically
the occurrence of one or more premature ventricular contractions) of a
canine heart to the effects of adrenaline after exposure to 9%, 10.5%
and 14% 1,1,1,2,3,3,3 -heptafluoropropane. The severity of the cardiac
responses increased dose-dependently. There were no treatment-related
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