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EC number: 207-079-2
CAS number: 431-89-0
Short description of key information on bioaccumulation potential result: The available data indicate that 1,1,1,2,3,3,3-heptafluoropropane is rapidly adsorbed upon inhalation. In rats, it is biotransformed at very low rates to hexafluoroacetone trihydrate (amount in the urine not quantifiable due to very low concentration), following 6 hours inhalation exposure. A study with human volunteers indicated that the substance is rapidly cleared at each exposure concentrations, with the substance concentration in blood below quantifiable limit (0.010 μg/m) at 24 h post-exposure.
Biotransformation of 1,1,1,2,3,3,3
-heptafluoropropane (HFC 277ea) was investigated in vivo in rats,
by exposing 3 male rats for 6 hours to a sinlge dose of 5000 ppm of the
test substance. After the exposure, the urine was collected for 24 hr
and analyzed for fluoride content using NMR technique (Koster et al., 1996).
identified hexafluoroacetone trihydrate in the urine of exposed rats. No
significant increase of inorganic fluoride was observed in urinary
excretion compared to untreated rats (0-48 hours after the end of the
exposure). Because of the very low concentrations of hexafluoroacetone
trihydrate present in the collected urine samples, the amount of this
metabolite could not be quantified.
Pharmacokinetics of 1,1,1,2,3,3,3
-heptafluoropropane was also investigated in the study with 8 male and
female human volunteers, using exposure concentrations 0, 1000, 2000,
4000 and 8000 ppm. Exposure was for 1 h on eight separate occasions,
separated generally by 7 days, two air exposures, two exposures to
dichlorodifluoromethane (at 1000 and 4000 ppm), and four exposures (at
1000, 2000, 4000 and 8000 ppm) to 1,1,1,2,3,3,3 -heptafluoropropane (Emmen
et al., 1999).
The blood concentration-time profile shows
that 1,1,1,2,3,3,3-heptafluoropropane was rapidly absorbed at each
exposure concentration in both males and females, with a rapid increase
and either maximum or near maximum concentration in blood observed after
15 min at each exposure concentrations.
Following the final exposure at 24-h, blood
samples was analyzed for 1,1,1,2,3,3,3-heptafluoropropane. All samples
were below the limit of quantification (0.010 μg/ml).
Also no metabolites were identified.
The results appear to indicate that the
substance is rapidly absorbed upon inhalation, but is also rapidly
eliminated, with no traces of substances detected in blood 24 hours
after exposure. Available data also appear to suggest that the majority
of the substance is excreted unmetabolized. Hexafluoroacetone trihydrate
was detected as an only metabolite in the urine of exposed rats;
however, its concentration was too low to be quantified.
As the substance is a gas, information on
dermal absorption is considered to be irrelevant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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