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EC number: 289-214-5
CAS number: 86261-90-7
Mortality: A summary of the mortality data for methyl methacrylate
is presented below.
group (ppm) Male Female
(0) 12/25 9/25
6/7 7/25 7/25
2000 12/25 10/25
No statistical differences were noted in the
mortality of the animals exposed to methyl methacrylate and those in the
control group. A statistically significant decrease in body weight was
observed in the first week for the female rats and in weeks one through
three in the male rats administered 2000 ppm methyl methacrylate. Water
consumption was reduced in the animals from the high-dose group;
however, it was reported that this finding tended to regress towards the
end of the study. Food consumption was not affected by the
administration of methyl methacrylate in the drinking water.
Hematologic values varied within normal ranges in all groups of
rats throughout the study, and urine concentrations of protein and
reducing substances showed no trends that appeared relatable to
Organ to body weight ratios obtained at sacrifice of 2-year
survivors differed from the controls only in significantly increased
kidney ratios in female rats receiving 2000 ppm of methyl methacrylate
(controls 0.0082 ± 0.0019; treated 0.0094 ± 0.0011).
Histopathologic findings showed no abnormalities or lesions, in
kind or incidence, not explicable on the basis of naturally occurring
ones in this strain of rat at this age.
Diet equivalents of the test materials were calculated from the
fluid and food consumption data.
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