2-(2-oxoimidazolidin-1-yl)ethyl methacrylate

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vitro / ex vivo

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

1997

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Adopted according to OECD SIDS (public available peer reviewed source).

Data source

Reference

Reference Type:

secondary source

Title:

Structure-activity Relationships in the Hydrolysis of Acrylate and Methacrylate Esters by Carboxylesterase In Vitro.

Author:

McCarthy, T.J. and Witz, G.

Year:

1997

Bibliographic source:

Toxicol., 116: 153-158; cited in OECD SIDS IUCLID data set (06.05.2009)

Materials and methods

Objective of study:

other: hydrolysis

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Hydrolysis of Acrylate Esters by Porcine Liver Carboxylesterase was tested in vitro.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Reference substance 001

Test material form:

other: liquid

Radiolabelling:

no

Results and discussion

Any other information on results incl. tables

Hydrolysis of Acrylate Esters by Porcine Liver Carboxylesterase in vitro:

Esters	Km (µM)	Vmax (nmol/min)
Ethyl acrylate	134 +/- 16.8	9 +/- 2.0
Ethyl methacrylate	159 +/- 90	5.2 +/- 2.5*
Butyl acrylate	33 +/- 8.5*	1.5 +/- 0.8*
Butyl methacrylate	72 +/- 28*	1.8 +/- 0.6*
Ethyleneglycol dimethacrylate	64 +/- 24*	6.9 +/- 2.4
Tetraethyleneglycol dimethacrylate	39 +/- 15*	2.9 +/- 1.0*

* Significantly different (p < 0.05) from ethyl acrylate