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EC number: 289-214-5
CAS number: 86261-90-7
No systemic clinical signs and no deaths related to treatment were noted
during the study.
After the challenge application, a discrete erythema (grade 1) was
observed in 1/10 animals of the control group at the 24-hour reading and
in another animal at the 48-hour reading.
In the treated group, at the 24-hour reading, a discrete, moderate or
intense erythema (grade 1, 2 or 3), together with an oedema and/or
crusts in 6/19 animals, was noted in 1/19, 5/19 and 12/19 animals,
respectively. At the 48-hour reading, a moderate or intense erythema
(grade 2 or 3), together with an oedema, dryness of the skin, crusts
and/or a brownish area in 16/19 animals, was recorded in 5/19 and 13/19
The cutaneous reactions observed in the animals of the treated group,
which were of higher incidence and severity than those recorded in the
animals of the control group, were attributed to delayed contact
Under our experimental conditions and according to the maximization
method of Magnusson and Kligman, the test item HYDROXYETHYL
IMIDAZOLIDONE METHACRYLATE (MEIO) (batch No. OP2981) induces delayed
contact hypersensitivity in 18/19 (95%) guinea pigs and therefore should
be considered as an extreme sensitizer.
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