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EC number: 289-214-5
CAS number: 86261-90-7
Significant levels of MMA were detected in the receptor fluid within 10
min of treatment in the presence or absence of occlusion. Under both
conditions, maximal rates of absorption were recorded within the first
hour of exposure, with higher values recorded following application
under occlusion compared with open exposure (274 compared with 107
mg/cm2/hr). The absorption rate for open application of MMA decreased
very rapidly and profoundly thereafter, with an average rate of 3.5
mg/cm2/hr recorded over the 10-hr period. A less marked decrease in
absorption rate was recorded over the same time period for occluded
epidermis (152 mg/cm2/hr). The differences in absorption rate were
paralleled by differences in the mean percentage dose of MMA absorbed.
Within 1 hr of treatment, considerably more MMA had been absorbed from
occluded, compared with unoccluded, tissue (2.41% and 0.48%,
respectively). Given that the rate of absorption from unoccluded
epidermis decreased very markedly 1 hr after application, it is not
surprising that the total percentage of the dose absorbed after 10 hr
had risen to only 0.56%. In contrast, after 10 hr of occlusion, 15% of
the total applied dose of MMA was detected in the receptor fluid. Given
the volatility of this material, the marked reduction in absorption of
MMA under unoccluded conditions is likely to be a result of the loss, by
evaporation, of MMA from the epidermal surface.
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