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EC number: 825-814-0
CAS number: 222721-94-0
SD = Standard Deviation
A test was performed to verify the mutagenic
potential of the test material 1,2,3-Propanetricarboxylic acid,
2-hydroxy-, tri-C14-15-alkyl esters on Salmonella typhimurium according
to Ames B.N., McCann J. and Yamasaki E. (1975).
The test was carried out on 5 strains of
Salmonella typhimurium (TA 1535, TA 1537, TA1538, TA 98, TA 100). The
mutagenic activity of the material was assessed by comparing the number
of revertant colonies induced with the positive control. This activity
was tested in the presence and absence of a metabolizing system and done
directly in a petri dish. The test material was tested at concentrations
of 100000, 10000, 1000, 100 and 10 µg/mL corresponding to doses of
10000, 1000, 100, 10 and 1 µg/petri dish. The results of the study can
be summarized as follows: The test material at maximum concentration 10
mg/petri dish produced no increase in number of revertant colonies in
comparison to the negative control. The result of the experiment with
tester strain TA 100 without metabolic activation could not be evaluated
because of a failure of the respective positive control. Nonetheless the
test material 1,2,3-Propanetricarboxylic acid, 2-hydroxy-,
tri-C14-15-alkyl esters was judged to be unable to induce mutations
under these conditions at least in Salmonella typhimurium tester strains
TA 1535, TA 1537, TA 1538 and TA 98.
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