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EC number: 825-814-0
CAS number: 222721-94-0
Table: Irritant/corrosive response
data for each animal at each observation time up to removal of each
animal from the test
Score at time point / Reversibility
Max. score: 4
Max. score: 2
Max. score: 3
Average 24h, 48h, 72h
Average time for reversion
*) Reversibility: c. = completely
reversible; n.c. = not completely reversible; n. = not reversible
An ocular irritation test was carried out on
test material Cosmacol ECL according to OECD Guideline 405.
The test was performed by placing the test
material in a single dose in the conjunctival sac of 6 albino male
rabbits at a dose of 0.1 g/animal. The animals eyes were examined 1, 24,
48 and 72 hours after the beginning of the test. The ocular areas
obvserved were the cornea, the iris and conjunctivae. The results showed
a slight congestion of the conjunctivae in 2 of 6 rabbits treated. This
irritation was seen one hour after the treatment, and disappeared 72
hours after treament.
It was concluded that Cosmacol ECL is to be
considered non-irritant to eyes.
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