Registration Dossier
Registration Dossier
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EC number: 825-814-0 | CAS number: 222721-94-0
Endpoint summary
Administrative data
Description of key information
An OECD 407-study was conducted on the source substance1, 2-Hydroxypropane-1,2,3-tricarboxylic acid, tri (hexyl, octyl, decyl) ester. There was no indication that the substance was toxic in male or female rats after repeated oral exposure up to 1000 mg/kg bw/d.
It is expected that the result is valid for the target substance 1,2,3 -Propanetricarboxylic acid, 2 -hydroxy-, tris(C14 -15 -alkyl) ester.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please see Analogue Justification
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 1 000 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no effects observed
- Remarks on result:
- other: no effect observed
- Key result
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
- Quality of whole database:
- Klimisch 1
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for selection of repeated
dose toxicity via oral route - systemic effects endpoint:
No long term study on the test
substance 1,2,3 -Propanetricarboxylic acid, 2 -hydroxy-, tris(C14 -15
-alkyl) ester exist. There was no indication that the source substance
2-Hydroxypropane-1,2,3-tricarboxylic acid, tri (hexyl, octyl, decyl)
ester was toxic in male or female rats after repeated oral exposure up
to 1000 mg/kg bw/d. It is likely that the same is valid for the test
substance.
Justification for classification or non-classification
No classification based on long term effects is indicated according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) or the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
