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EC number: 825-814-0
CAS number: 222721-94-0
SD = Standard Deviation
A test was performed to verify the mutagenic
potential of the test material 1,2,3-Propanetricarboxylic acid,
2-hydroxy-, tri-C14-15-alkyl esters on Salmonella typhimurium according
to Ames B.N., McCann J. and Yamasaki E. (1975).
The test was carried out on 5 strains of
Salmonella typhimurium (TA 1535, TA 1537, TA1538, TA 98, TA 100). The
mutagenic activity of the material was assessed by comparing the number
of revertant colonies induced with the positive control. This activity
was tested in the presence and absence of a metabolizing system and done
directly in a petri dish. The test material was tested at concentrations
of 100000, 10000, 1000, 100 and 10 µg/mL corresponding to doses of
10000, 1000, 100, 10 and 1 µg/petri dish. The results of the study can
be summarized as follows: The test material at maximum concentration 10
mg/petri dish produced no increase in number of revertant colonies in
comparison to the negative control. The result of the experiment with
tester strain TA 100 without metabolic activation could not be evaluated
because of a failure of the respective positive control. Nonetheless the
test material 1,2,3-Propanetricarboxylic acid, 2-hydroxy-,
tri-C14-15-alkyl esters was judged to be unable to induce mutations
under these conditions at least in Salmonella typhimurium tester strains
TA 1535, TA 1537, TA 1538 and TA 98.
The target substance 1,2,3
-Propanetricarboxylic acid, 2 -hydroxy-, tris(C14 -15 -alkyl) ester
did not cause mutagenic effects towards
bacteria in a standard Ames test. Also the source substance Tri (hexyl,
octyl, decyl) citrate and the structurally related substance
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, tris(C12-13-branched-alkyl)
ester did not cause mutagenicity with and without metabolic activation
in Ames tests. The structurally related source substance Tri-C18 -22
(even numbered)-alkyl 2-hydroxypropane-1,2,3-tricarboxylate, is not
mutagenic in mouse lymphoma L5178Y cells, in either the absence or the
presence of S9 mix, when tested to the maximum practicable concentration
of 1000 µg/mL. The structurally related substance Tri (hexyl, octyl,
decyl) citrate did not induce structural chromosomal aberrations in the
V79 Chinese hamster cell line. Therefore it is concluded that the test
substance has no mutagenic properties.
Endpoint Conclusion: No adverse effect observed (negative)
No classification for mutagenicity is
indicated according to the general classification and labeling
requirements for dangerous substances and preparations (Directive
67-548-EEC) or the classification, labeling and packaging (CLP)
regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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