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EC number: 928-779-0
CAS number: -
Dose range finding study 1
In the dose range finding study 6 animals (2
males per group) were dosed intraperitoneally with 2000, 1000 and 250
mg/kg body weight (groups A, B and C respectively). The results of this
dose range finding study are presented in Table 1.
Table 1 Mortality and systemic toxic signs
after treatment of the test item in the dose range finding study
A=died; B=showed no abnormalities; C=ataxia; E=tremor; F=lethargy
Micronucleus Test 2 (main test):
Micronucleated polychromatic erythrocytes
The mean number of micronucleated
polychromatic erythrocytes per group and the mean ratio of polychromatic
to normochromatic erythrocytes are presented in Table 2. The indivudual
data are described in Table 3. The mean number of micronucleated
polychromatic erythrocytes scored in the test item treated groups were
compared with the corresponding solvent control group.
No biologically significant increase in the
frequency of micronucleated polychromatic erythroytes was observed in
the polychromatic erythrocytes of the bone marrow of the test item
treated animals compared to the vehicle treated animals.
The incidence of micronucleated
polychromatic erythrocytes in the bone marrow of all negative control
animals was within the historical solvent control data range.
Cyclophosphamide, the positive control
substance, induced a statistically significant increase in the number of
micronucleated polychromatic erythrocytes. Hence, the acceptability
criteria of the test were met.
Table 2: Mean number of micronucleated
polychromatic erythrocytes per 2000 polychromatic erythrocytes and ratio
of polychromatic/norchromatic erythrocytes
Vehicle = corn oil
CP = Cyclophoshamide
* Five animals per treatment group
** Significantly different from
corresponding control group (Wilcoxon Rank Sum Test, P <= 0.01)
Table 3: Individual data
A: intraperitoneal injection of corn oil
B-C: intraperitoneal injection of the test
D: intraperitoneal injection of
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