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Diss Factsheets

Administrative data

Endpoint:
appearance / physical state / colour
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 2017
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
Reason / purpose for cross-reference:
reference to same study
Reference
Endpoint:
melting point/freezing point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2017-05
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 102 (Melting point / Melting Range)
Qualifier:
according to guideline
Guideline:
EU Method A.1 (Melting / Freezing Temperature)
GLP compliance:
yes (incl. QA statement)
Type of method:
capillary method
Key result
Decomposition:
yes
Decomp. temp.:
200 °C

In the preliminary capillary test accoring to OECD guideline 102 and EC method A.1. no melting point could be observed as the test substance started to decompose at a temperature of 200 °C. The test item began to change its color from white over yellow and light red to black at 200°C . This behavior of the test item leads to the conclusion that TH 1165 Keton I BR decomposes and has no melting point.

Conclusions:
No melting point could be observed as the test item started to decompose at a temperature of 200 °C.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2017

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The Appearance/physical state and colour were sourced from the review of melting point test (as determined according to EC Methods A.1 and OECD Test Guidelines 102 (1995)).
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(3,5-Dihydroxyphenyl)-1-oxo-2-(N-1-(4-methoxyphenyl)isopropylamino)ethane Hydrobromide
EC Number:
928-779-0
Molecular formula:
C18-H21-N-O4 x HBr
IUPAC Name:
1-(3,5-Dihydroxyphenyl)-1-oxo-2-(N-1-(4-methoxyphenyl)isopropylamino)ethane Hydrobromide
Test material form:
solid: particulate/powder

Results and discussion

Physical state at 20°C and 1013 hPa:
solid
Remarks:
Based on the test item decomposing before melting at a tempreature of 200°C and as described in the study referred to.
Form / colour / odour
Key result
Form:
solid: particulate/powder
Colour:
white
Substance type:
organic

Applicant's summary and conclusion

Conclusions:
The physical state and appearance of the test item is a white solid/particulate at 20°C and 1013 hPa, based on the test item having no melting point and decomposing before melting at a tempereture of about 200°C, as described in the study referred to. The result is considered to be reliable.