1-(3,5-Dihydroxyphenyl)-1-oxo-2-(N-1-(4-methoxyphenyl)isopropylamino)ethane Hydrobromide

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Feb 27, 2017 - Mar 6, 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Reference

Endpoint:

appearance / physical state / colour

Type of information:

experimental study

Adequacy of study:

key study

Study period:

Feb 27, 2017 - Mar 6, 2017

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

The Appearance/physical state and colour were sourced from the review of melting point test (as determined according to EC Methods A.1 and OECD Test Guidelines 102 (1995)).

GLP compliance:

no

Physical state at 20°C and 1013 hPa:

solid

Remarks:

Based on the test item decomposing before melting at a tempreature of 200°C and as described in the study referred to.

Key result

Form:

solid: particulate/powder

Colour:

white

Substance type:

organic

Conclusions:

The physical state and appearance of the test item is a white solid/particulate at 20°C and 1013 hPa, based on the test item having no melting point and decomposing before melting at a tempereture of about 200°C, as described in the study referred to. The result is considered to be reliable.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

GLP compliance:

yes (incl. QA statement)

Type of method:

capillary method

Test material

Test material information

Constituent 1

Reference substance name:

1-(3,5-dihydroxyphenyl)-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-one hydrobromide

EC Number:

928-779-0

Cas Number:

1178555-23-1

Molecular formula:

C18-H21-N-O4 x HBr

IUPAC Name:

1-(3,5-dihydroxyphenyl)-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethan-1-one hydrobromide

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

TH 1165 Keton I Br
Batch number 600CC
solid/white
99.9% w/w purity
MW=396.3 g/mol
no density given
expiry date: 31 Mar 2020
storage conditions: ambient (5-30 deg C), dark, dry

Results and discussion

Melting / freezing point

Key result

Decomposition:

yes

Decomp. temp.:

200 °C

Any other information on results incl. tables

In the preliminary capillary test accoring to OECD guideline 102 and EC method A.1. no melting point could be observed as the test substance started to decompose at a temperature of 200 °C. The test item began to change its color from white over yellow and light red to black at 200°C . This behavior of the test item leads to the conclusion that TH 1165 Keton I BR decomposes and has no melting point.

Applicant's summary and conclusion

Conclusions:

The test item has no melting point down to 30degC using a preliminary test according to OECD 102 (1995) and EC method A.1 as TH 1165 Keton I BR started to decompose at a temperature of about 200degC (473 K). This behavior of the test item leads to the conclusion that TH 1165 Keton I BR decomposes and has no melting point