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EC number: 617-081-9
CAS number: 80473-92-3
Information available from acute oral toxicity test showed adverse
effects to female mice at highest dose of 2000 mg/kg bw. LD50 for oral
acute toxicity was not determined.
From the results of the study, the toxicity rating for GR46580X
(Thio-acid) was harmful.
The acute oral toxicity of GR46580X was evaluated in CR/H mice. The test
material was administered by gavage as suspensions in 0.5% aqueous
Methocel K15M Premium (hydroxypropyl methyl cellulose, viscosity type
15000). Groups of 10 mice (5 male, 5 female) were used. The animals were
observed for up to 14 days after dosing. The acute oral toxicity of the
test material was assessed on the basis of clinical signs.
Clinical signs of toxicity were noted in both sexes on the day of dosing
with 2000 mg/kg GR46580X and one female was killed in extremis
one day after dosing. There were no clinical signs of toxicity at a dose
level of 200 mg/kg GR46580X and the material was classified as harmful.
Available test results not sufficient for classification for acute
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